The Canon Pixma TS8120 has a very interesting cartridge alignment, based on the 6 individual ink system included. As you first order your printer, you will receive all 6 cartridges: pigmented black (Canon PGI-280), black (Canon CLI-281), cyan (Canon CLI-281), magenta (Canon CLI-281), yellow (Canon CLI-281) and photo blue (Canon CLI-281). When one or all the cartridges run out of ink, you can replace each one of them individually, or you can opt for a more convenient combo pack. In order for the printer to work, each cartridge needs to be installed and have a minimum amount of ink to start printing. Whenever one of the cartridges is running low on ink, the printer will activate the appropriate alert.